XU Gang，WANG Jin-ming，MA Shu-hui，ZHAN Ya-qi，MA Hai-li. Effects of Fluoride on the Expression of ERK Signaling Pathway Associated Gene and Proteins in the Splenic Lymphocytes of Mouse[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(11): 1888-1894.
［1］王俊东，董希德.畜禽营养代谢与中毒病［M］.北京：中国林业出版社，2001：223-247.
［2］WANG J，HONG J，LI J，et al.Effect of high fluoride and low protein on tooth matrix development in goats［J］.Fluoride，2002，35(1)：51-55.
［3］WAN S，ZHANG J，WANG J.Effects of high fluoride on sperm quality and testicular histology in male rats［J］.Fluoride，2006，39(1)：17-21.
［4］ZHANG M，WANG A，HE W，et al.Effects of fluoride on the expression of NCAM，oxidative stress，and apoptosis in primary cultured hippocampal neurons［J］.Toxicology，2007，236(3)：208-216.
［5］LOFTENIUS A，ANDERSSON B，BUTLER J，et al.Fluoride augments the mitogenic and antigenic response of human blood lymphocytes in vitro ［J］.Caries Res，1999，33(2)：148-155.
［6］张侃侃.氟对大鼠脾脏MAPK信号通路相关基因及蛋白表达的影响［D］.山西：山西农业大学，2010.
［7］ROBINSON M J，COBB M H.Mitogen-activated protein kinase pathways［J］.Curr Opin Cell Biol，1997，9(2)：180-186.
［8］马莲环，刘建.ERK1/2 的研究进展［J］.国外医学：生理、病理科学与临床分册，2005，25(3)：279-282.
［9］TRAVERSE S，GOMEZ N，PATERSON H，et al.Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells.Comparison of the effects of nerve growth factor and epidermal growth factor［J］.Biochem J，1992，288（2）：351-355.
［10］THRANE E V，REFSNES M，THORESEN G H，et al.Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK［J］.Toxicol Sci，2001，61(1)：83-91.
［11］韩博，尹文利，史言，等.氟对动物机体免疫功能的影响［J］.动物医学进展，1999，20(3)：9-11.
［12］张广和，于志慧，杜小平，等.氟中毒对小鼠脾脏组织形态学研究［J］.国外畜牧学（猪与禽），2009，29(3)：105-107.
［13］郭晓英，孙贵范，金亚平，等.氟对小鼠脾淋巴细胞增殖反应的影响［J］.中国地方病学杂志，2001,20(11)：32-33.
［14］姜勇，罗深秋.细胞信号转导的分子基础与功能调控［M］.北京：科学出版社，2005.
［15］KYRIAKIS J M，AVRUCH J.Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation［J］.Physiol Rev，2001，81(2)：807-869.
［16］MURPHY L O，SMITH S，CHEN R H，et al.Molecular interpretation of ERK signal duration by immediate early gene products［J］.Nat Cell Biol，2002，4(8)：556-564.
［17］LEWIS T S，SHAPIRO P S，AHN N G.Signal transduction through MAP kinase cascades［J］.Adv Cancer Res，1998，74：49-139.
［18］LAU K H，BAYLINK D J.Molecular mechanism of action of fluoride on bone cells［J］.J Bone Miner Res，1998，13(11)：1660-1667.
［19］BOGATCHEVA N V，WANG P，BIRUKOVA A A，et al. Mechanism of fluoride-induced MAP kinase activation in pulmonary artery endothelial cells［J］.Am J Physiol Lung Cell Mol Physiol，2006，290(6)：L1139-L1145.
［20］RIDLEY W，MATSUOKA M.Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells［J］.Toxicol Lett，2009，188(3)：180-185.
［21］ZHANG Y，LI W，CHI H S，et al.JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitro［J］. Matrix Biol，2007，26(8)：633-641.
